Washington University, St. Louis: Inclusion/Exclusion Criteria

Inclusion Criteria

• Subjects (smokers with HIV)
  • 35-75 years of age
  • At least 15 pack-year smoking history
  • Deemed capable of participating in informed consent in English
• Controls (smokers without emphysema)
  • 35-60 years of age
  • GOLD class 0 or 1
  • No or minimal emphysema on chest CT scan
  • At least 15 pack-year smoking history
  • Deemed capable of participating in informed consent in English

Exclusion Criteria

• Recent illness, defined as increased cough, sputum production, worsening malaise, or need for unscheduled physician visit in the month prior to enrollment
• Coexisting chronic inflammatory or collagen vascular disease, immunodeficiency (other than HIV), malignancy, or organ transplant
• CT evidence of lung disease other than emphysema including significant fibrosis, bronchiectasis, consolidation, or indeterminate nodules (will result in some subjects being excluded after consent)
• Congenital abnormalities of the lung or previous surgery on the lung